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1. (WO2018122689) NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
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Pub. No.: WO/2018/122689 International Application No.: PCT/IB2017/058204
Publication Date: 05.07.2018 International Filing Date: 20.12.2017
IPC:
C07C 49/84 (2006.01) ,A61K 31/121 (2006.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
76
Ketones containing a keto group bound to a six-membered aromatic ring
84
containing ether groups, groups, groups, or groups
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
121
acyclic
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" [IT/IT]; Piazzale Aldo Moro, 5 I-00185 Roma, IT
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA [IT/IT]; Via Morego, 30 I-16163 Genova, IT
Inventors:
BOTTA, Bruno; IT
SCREPANTI, Isabella; IT
TOTTONE, Luca; IT
ZHDANOSKAYA, Nadezda; IT
INGALLINA, Cinzia; IT
GIULIMONDI, Francesca; IT
QUAGLIO, Deborah; IT
PALERMO, Rocco; IT
MORI, Mattia; IT
GHIRGA, Francesca; IT
Agent:
FREYRIA FAVA, Cristina; IT
Priority Data:
10201600013236029.12.2016IT
Title (EN) NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
(FR) INHIBITEURS DE NOTCH DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA LEUCÉMIE LYMPHOBLASTIQUE AIGUË À LYMPHOCYTES T
Abstract:
(EN) Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
(FR) La présente invention concerne des composés de formule (I) à activité antitumorale destinés à être utilisés dans le traitement de la leucémie lymphoblastique aiguë à lymphocytes T (T-ALL).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Italian (IT)