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1. (WO2018122550) OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

Pub. No.:    WO/2018/122550    International Application No.:    PCT/GB2017/053822
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Wed Dec 20 00:59:59 CET 2017
IPC: C07D 413/14
C07D 413/12
C07D 417/12
C07D 417/14
C07D 487/04
C07D 263/48
A61P 35/00
A61K 31/422
Applicants: LIFEARC
Inventors: OSBORNE, Simon
LARGE, Jonathan
Title: OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
Abstract:
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: • B is an aryl or heteroaryl group optionally substituted by one or more R10 groups; and * X is selected from 0, (CR11 R12 ) p and (CR11 R12 ) p CO. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).