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1. (WO2018122205) NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF

Pub. No.:    WO/2018/122205    International Application No.:    PCT/EP2017/084541
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: C07K 16/44
C07D 495/04
G01N 33/82
A61K 47/51
A61K 31/4188
C07K 16/00
C07K 16/40
G01N 33/53
Applicants: F. HOFFMANN-LA ROCHE AG
ROCHE DIAGNOSTICS GMBH
ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventors: GERG, Michael
HEINDL, Dieter
HILLRINGHAUS, Lars
HIRZEL, Klaus
HOJER, Caroline Dorothea
HUBER, Florian
JOSEL, Hans-Peter
MEIER, Thomas
SCHRAEML, Michael
VOSS, Edgar
Title: NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF
Abstract:
The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.