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|1. (WO2018122204) NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF|
|Applicants:||F. HOFFMANN-LA ROCHE AG
ROCHE DIAGNOSTICS GMBH
ROCHE DIAGNOSTICS OPERATIONS, INC.
HOJER, Caroline Dorothea
VON PROFF, Leopold
|Title:||NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF|
The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.