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1. (WO2018122196) BIOPROCESS PURIFICATION SYSTEM AND METHOD

Pub. No.:    WO/2018/122196    International Application No.:    PCT/EP2017/084495
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: G01N 30/46
B01D 15/18
Applicants: GE HEALTHCARE BIO-SCIENCES AB
Inventors: HYCKENBERG, Key
BERG, Mikael. Johan Helmer Eugen
SKOGLAR, Helena
MALMQUIST, Gunnar
MATHIASSON, Linda
MATTSSON, Lars, Henning Ivar
SENDABO, Sara
Title: BIOPROCESS PURIFICATION SYSTEM AND METHOD
Abstract:
The present invention relates to a method for controlling a bioprocess purification system comprising a continuous chromatography configured to operate with at least three columns and configured for cyclic operation, wherein the continuous purification is performed on a sample comprising a target product having desired characteristics. The method comprises detecting (82) at least one parameter indicative of characteristics of the target product, performing (83)real time trend analysis of each detected at least one parameter to identify a deviation from the desired characteristics of the target product, and controlling (84) the bioprocess purification system to meet the desired characteristics based on the identified deviation, whereby the target characteristics is within a pre-determined range.