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1. (WO2018122194) FAILURE RECOVERY IN CELL CULTURE BIOREACTORS

Pub. No.:    WO/2018/122194    International Application No.:    PCT/EP2017/084483
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: C12M 1/00
C12M 3/06
C12M 1/36
Applicants: GENERAL ELECTRIC COMPANY
GE HEALTHCARE UK LIMITED
Inventors: RAMAKRISHNA, Manoj
BHARGAV, Anoop
PAI, Umesh
Title: FAILURE RECOVERY IN CELL CULTURE BIOREACTORS
Abstract:
Disclosed is a cell culture system comprising a first cell culture bioreactor system (10) for culturing cells to a predetermined cell density or quantity, the system including a bioreactor volume (20), a process controller (30), process control devices (32) which provide inputs (16) for the culture volume and culture parameter measurement devices (14), wherein the process controller is operable according to plural control program steps to control the process devices to provide inputs for a suitable cell culture environment in the bioreactor volume, and is further operable according to control program steps modified by feedback values from the culture parameter measurement devices, and comprises a memory (36) operable to record data indicative of the progress of the control program steps. Failure of the system can be rectified by moving the bioreactor volume to another similar system which has access to data indicative of any incomplete program steps which steps may have been modified by feedback from the measurement devices.