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1. (WO2018122191) MONITORING PERFORMANCE IN CONTINUOUS CHROMATOGRAPHY

Pub. No.:    WO/2018/122191    International Application No.:    PCT/EP2017/084478
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: G01N 30/86
B01D 15/18
G01N 30/44
G01N 30/46
Applicants: GE HEALTHCARE BIO-SCIENCES AB
Inventors: HYCKENBERG, Key
BERG, Mikael, Johan Helmer Eugen
SKOGLAR, Helena
MALMQUIST, Gunnar
CARLSTEN, Mikael
LUNDQVIST, Roger
ANDERSSON, Dan
MATHIASSON, Linda
Title: MONITORING PERFORMANCE IN CONTINUOUS CHROMATOGRAPHY
Abstract:
The present invention relates to a method for monitoring operational status in continuous chromatography configured to operate with at least three columns adapted for cyclic use for continuous purification of a target product when feeding the continuous chromatography with a sample containing the target product. The method comprises detecting (81) at least one parameter indicative of a selected function in the continuous chromatography,performing (82) real time trend analysis of the detected parameter to identify a deviating behaviour of the selected function, and initiate (83) actions to eliminate or reduce the effect of the identified deviating behaviour where by the performance of the continuous chromatography is maintained.