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|1. (WO2018122191) MONITORING PERFORMANCE IN CONTINUOUS CHROMATOGRAPHY|
|Applicants:||GE HEALTHCARE BIO-SCIENCES AB
BERG, Mikael, Johan Helmer Eugen
|Title:||MONITORING PERFORMANCE IN CONTINUOUS CHROMATOGRAPHY|
The present invention relates to a method for monitoring operational status in continuous chromatography configured to operate with at least three columns adapted for cyclic use for continuous purification of a target product when feeding the continuous chromatography with a sample containing the target product. The method comprises detecting (81) at least one parameter indicative of a selected function in the continuous chromatography,performing (82) real time trend analysis of the detected parameter to identify a deviating behaviour of the selected function, and initiate (83) actions to eliminate or reduce the effect of the identified deviating behaviour where by the performance of the continuous chromatography is maintained.