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1. (WO2018121802) VACCINE COMPOSITION COMPRISING A MUTATION OF HUMAN INTERLEUKIN-15

Pub. No.:    WO/2018/121802    International Application No.:    PCT/CU2017/050008
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 21 00:59:59 CET 2017
IPC: C07K 16/24
A61K 39/00
Applicants: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
Inventors: RODRIGUEZ ALVAREZ, Yunier
MORERA DÍAZ, Yanelys
GERONIMO PEREZ, Haydeé
Title: VACCINE COMPOSITION COMPRISING A MUTATION OF HUMAN INTERLEUKIN-15
Abstract:
The invention relates to a vaccine composition comprising a mutation of human interleukin-15 (IL-15). The invention also relates to the use of said polypeptide mutation of human IL-15 in order to produce a medicine for the active immunotherapy for a disease relating to the over-expression of IL-15, including certain autoimmune diseases and haematologic neoplasia. The administration of a therapeutically effective quantity of vaccine, comprising the polypeptide mutation of human IL-15 according to the invention, to an individual in need, represents a method for the treatment of diseases relating to the over-expression of IL-15.