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1. (WO2018121743) MIR-96 FOR PROTECTING LIVERS, MUSCLES, LUNGS, AND KIDNEYS, FOR REGULATING CONTENT OF TOTAL PROTEIN AND CONTENT OF ALBUMIN IN BLOOD, AND FOR INSULIN RESISTANCE
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Pub. No.: WO/2018/121743 International Application No.: PCT/CN2017/119889
Publication Date: 05.07.2018 International Filing Date: 29.12.2017
Chapter 2 Demand Filed: 29.10.2018
IPC:
A61K 48/00 (2006.01) ,A61K 31/7088 (2006.01) ,A61P 3/06 (2006.01) ,A61P 1/16 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
Applicants:
昆山彭济凯丰生物科技有限公司 PENGEKIPHEN BIOTECH LIMITED [CN/CN]; 中国江苏省昆山市 高新区元丰路168号 Yuanfeng Road 168, New & Hi-Tech Industrial Development Zone Kunshan, Jiangsu 215300, CN
Inventors:
彭长庚 PENG, Changgeng; CN
温婷 WEN, Ting; CN
Agent:
北京润平知识产权代理有限公司 RUNPING & PARTNERS; 中国北京市 海淀区北四环西路9号银谷大厦515室 Suite 515, Yingu Mansion, No. 9 Beisihuanxilu, Haidian District Beijing 100190, CN
Priority Data:
201611242981.629.12.2016CN
Title (EN) MIR-96 FOR PROTECTING LIVERS, MUSCLES, LUNGS, AND KIDNEYS, FOR REGULATING CONTENT OF TOTAL PROTEIN AND CONTENT OF ALBUMIN IN BLOOD, AND FOR INSULIN RESISTANCE
(FR) MIR-96 POUR PROTÉGER LE FOIE, LES MUSCLES, LES POUMONS ET LES REINS, POUR RÉGULER LA TENEUR EN PROTÉINE TOTALE ET LA TENEUR EN ALBUMINE DANS LE SANG, ET POUR LA RÉSISTANCE À L'INSULINE
(ZH) miR-96用于保护肝、肌肉、肺和肾及调控血液总蛋白和白蛋白含量及胰岛素抵抗
Abstract:
(EN) Provided are an application of miR-96 function inhibition in protecting livers and muscles, in preventing and/or treating kidney diseases and complications thereof and diseases and symptoms related to the decrease of the content of total protein and the content of albumin in blood, and in insulin resistance, an application of miR-96 function enhancement in enhancing lung function, a method for miR-96 function enhancement, and an application of the detection of miR-96 expression level in blood in predicting whether an individual has the risk of suffering liver, kidney and lung diseases. By making a miR-96 inhibitor be in contact with a target cell expressing miR-96, diseases caused by the increase of the amount of miR-96 can be effectively prevented and/or treated; in addition, a miR-96 enhancer can increase lung weight, thereby protecting lung function.
(FR) L'invention concerne une application de l'inhibition de la fonction miR-96 dans la protection du foie et des muscles, dans la prévention et/ou le traitement de maladies rénales et de leurs complications et de maladies et symptômes liés à la diminution de la teneur en protéine totale et de la teneur en albumine dans le sang, et dans la résistance à l'insuline, une application de l'amélioration de la fonction miR-96 dans l'amélioration de la fonction pulmonaire, un procédé d'amélioration de la fonction miR-96, et une application de la détection du niveau d'expression de miR-96 dans le sang pour prédire si un individu risque de souffrir de maladies hépatiques, rénales et pulmonaires. En mettant un inhibiteur de miR-96 en contact avec une cellule cible exprimant miR-96, des maladies provoquées par l'augmentation de la quantité de miR-96 peuvent être efficacement évitées et/ou traitées ; en outre, un activateur de miR-96 peut augmenter le poids pulmonaire, et ainsi protéger la fonction pulmonaire.
(ZH) 提供了抑制miR-96的功能在保护肝脏和肌肉,及预防和/或治疗肾病及其并发症、与血液中总蛋白和/或白蛋白含量降低相关的疾病和症状及胰岛素抵抗中的应用,增强miR-96的功能在增强肺功能中的应用、增强miR-96的功能的方法及检测miR-96在血液中的表达量在预测个体是否具有患肝、肾和肺病的风险中的应用。通过将miR-96抑制剂与表达miR-96的靶细胞接触,能有效预防和/或治疗miR-96量升高所引起的疾病,同时,miR-96增强剂可增加肺重,从而可对肺功能进行保护。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)