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1. (WO2018121712) NOVEL CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF

Pub. No.:    WO/2018/121712    International Application No.:    PCT/CN2017/119711
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 30 00:59:59 CET 2017
IPC: C07K 19/00
A61K 39/00
Applicants: NANJING LEGEND BIOTECH CO., LTD.
南京传奇生物科技有限公司
Inventors: FAN, Xiaohu
范晓虎
ZHUANG, Qiuchuan
庄秋传
WANG, Pingyan
王平艳
YANG, Lei
杨蕾
ZHENG, Xiujun
郑修军
HAO, Jiaying
郝佳瑛
LIU, Shaobo
刘少波
Title: NOVEL CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF
Abstract:
A novel chimeric antigen receptor and use thereof. The novel chimeric antigen receptor consists of a signal peptide, an antigen-binding domain, a transmembrane region and an intracellular signal domain, and comprises 4-1BB signal peptide and/or 4-1BB molecular transmembrane region. Nucleic acid sequences of various chimeric antigen receptors are separated, and a chimeric antigen receptor and CAR-T cells specific for CD19 malignant tumor antigen are provided. In blood cell line malignant tumors killing tests, the ability of immune cells to specifically recognize tumor cells was significantly increased, and the killing activity against tumor cells was also increased.