Search International and National Patent Collections

1. (WO2018121604) MULTI-TARGET CHIMERIC ANTIGEN RECEPTOR

Pub. No.:    WO/2018/121604    International Application No.:    PCT/CN2017/118980
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 28 00:59:59 CET 2017
IPC: C07K 19/00
C12N 15/62
C12N 15/63
C12N 5/10
G01N 33/68
A61K 35/17
A61P 35/00
Applicants: TIMMUNE BIOTECH INC.
天津天锐生物科技有限公司
Inventors: WANG, Lei
王磊
GAO, Bin
高斌
WU, Yasong
吴亚松
SI, Yuan
司远
LV, Dan
吕丹
WEI, Qing
魏卿
Title: MULTI-TARGET CHIMERIC ANTIGEN RECEPTOR
Abstract:
Disclosed in the present invention is a multi-target chimeric antigen receptor. Provided in the present invention is a multi-target chimeric antigen receptor consisting of a main peptide chain and an auxiliary peptide chain; the main peptide chain comprises an antigen binding domain A, an auxiliary peptide chain connecting domain B, a transmembrane domain C and an intracellular signaling domain D; the auxiliary peptide chain comprises a main peptide chain connecting domain F; the antigen binding domain A is a polypeptide having an antigen-binding function; the auxiliary chain connecting domain B and the main peptide connecting domain F are combined with each other; the transmembrane domain C is a transmembrane domain of any membrane-binding protein or a transmembrane protein; and the intracellular signaling domain D comprises a primary signaling region. The multi-target chimeric antigen receptor of the present invention can bind to different antigens through the two antigen binding domains thereof, and mediates specific cell killing; and a cytokine and cytokine receptor complex playing the role of a cytokine are introduced into the multi-target chimeric antigen receptor of the present invention.