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1. (WO2018121560) UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
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Pub. No.: WO/2018/121560 International Application No.: PCT/CN2017/118844
Publication Date: 05.07.2018 International Filing Date: 27.12.2017
IPC:
C07D 405/14 (2006.01) ,C07D 249/08 (2006.01) ,C07D 215/16 (2006.01) ,C07D 217/02 (2006.01) ,C07D 233/36 (2006.01) ,A61K 45/06 (2006.01) ,A61K 31/165 (2006.01) ,A61K 31/357 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/505 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for C07D 405/14][IPC code unknown for C07D 249/08][IPC code unknown for C07D 215/16][IPC code unknown for C07D 217/02][IPC code unknown for C07D 233/36][IPC code unknown for A61K 45/06][IPC code unknown for A61K 31/165][IPC code unknown for A61K 31/357][IPC code unknown for A61K 31/40][IPC code unknown for A61K 31/505][IPC code unknown for A61P 35]
Applicants:
深圳微芯生物科技有限责任公司 SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. [CN/CN]; 中国广东省深圳市 南山区高新中一道十号深圳生物孵化基地2号楼601-606室 2-601~606, BIO-Incubator Gaoxin C, 1st Ave., Hi-Tech Industrial Park, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors:
杨千姣 YANG, Qianjiao; CN
鲁先平 LU, Xianping; CN
李志斌 LI, Zhibin; CN
辛利军 XIN, Lijun; CN
宋永连 SONG, Yonglian; CN
付超 FU, Chao; CN
Agent:
深圳市深佳知识产权代理事务所(普通合伙) SHENPAT INTELLECTUAL PROPERTY AGENCY; 中国广东省深圳市 国贸大厦15楼西座1521室 Room 1521 West Block, Guomao Building Shenzhen, Guangdong 518014, CN
Priority Data:
201611245660.129.12.2016CN
Title (EN) UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
(FR) COMPOSÉ D'URÉE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 脲类化合物、其制备方法及其应用
Abstract:
(EN) The present invention relates to a urea compound and a preparation method and an application thereof. The structure of the present compound is represented by formula (I), the definition of each variable in the formula being as described in the description. The compound can block interaction between the PD-1/PD-L1 signalling pathways. The compound of the present invention can be used for treating or preventing diseases related to the signalling pathways, such as cancer, autoimmune disease, chronic infectious disease, and other diseases.
(FR) La présente invention concerne un composé d'urée, son procédé de préparation et son application. La structure du composé de la présente invention est représentée par la formule (I), la définition de chaque variable dans la formule étant telle que décrite dans la description. Le composé peut bloquer l'interaction entre les voies de signalisation PD-1/PD-L1. Le composé de la présente invention peut être utilisé pour traiter ou prévenir des maladies associées aux voies de signalisation, telles que le cancer, une maladie auto-immune, une maladie infectieuse chronique et d'autres maladies.
(ZH) 本发明涉及一种脲类化合物、其制备方法及其应用。所述化合物的结构如式(I)所示,式中各变量的定义如说明书所述。所述化合物能够阻断PD-1/PD-L1信号通路之间的相互作用。本发明化合物可用于治疗/预防与该信号通路相关的疾病,例如癌症、自身免疫性疾病、慢性感染性疾病及其它疾病。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)