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1. (WO2018121550) QUINAZOLINE COMPOUND AND PREPARATION METHOD, APPLICATION, AND PHARMACEUTICAL COMPOSTION THEREOF

Pub. No.:    WO/2018/121550    International Application No.:    PCT/CN2017/118771
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Wed Dec 27 00:59:59 CET 2017
IPC: C07D 405/14
C07D 401/14
C07D 401/04
A61K 31/517
A61K 31/5377
Applicants: INSTITUTE OF MATERIA MEDICA ,CHINESE ACADEMY OF MEDICAL SCIENCES
中国医学科学院药物研究所
Inventors: XU, Heng
许恒
CHEN, Xiaoguang
陈晓光
LIN, Songwen
林松文
JI, Ming
季鸣
JIN, Jing
金晶
WU, Deyu
吴德雨
WANG, Yangchun
王春阳
LV, Yuanhao
吕元皓
Title: QUINAZOLINE COMPOUND AND PREPARATION METHOD, APPLICATION, AND PHARMACEUTICAL COMPOSTION THEREOF
Abstract:
The present invention relates to a quinazoline compound and a preparation method, an application, and a pharmaceutical compostion thereof. The present quinazoline compound is represented by the formula (I), is a phosphatidylinositol 3-kinase (PI3K) inhibitor, and can be used for preventing and/or treating diseases related to PI3K activity, such as cancer, immunological disease, cardiovascular disease, viral infection, inflammation, metabolic/endocrine function disorders or neurological disease.