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1. (WO2018121475) SINGLE-DOMAIN ANTIBODY RECOGNIZING COMPLEX FORMED BY HLA-A2 MOLECULE AND SLLMWITQC SHORT PEPTIDE

Pub. No.:    WO/2018/121475    International Application No.:    PCT/CN2017/118287
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Tue Dec 26 00:59:59 CET 2017
IPC: C07K 16/30
C07K 16/46
C12N 15/13
C12N 15/62
Applicants: TIMMUNE BIOTECH INC.
天津天锐生物科技有限公司
Inventors: LV, Lihui
吕丽慧
GAO, Bin
高斌
GU, Mingzhu
古明珠
LIU, Ying
刘莹
Title: SINGLE-DOMAIN ANTIBODY RECOGNIZING COMPLEX FORMED BY HLA-A2 MOLECULE AND SLLMWITQC SHORT PEPTIDE
Abstract:
Provided is a single-domain antibody capable of specifically recognizing an HLA-A2/SLLMWITQC complex. The single-domain antibody comprises CDR1, CDR2, and CDR3 amino acid sequences having a specific recognition effect. The single-domain antibody can be used in preparing various fusion proteins and polyspecific antibodies, and in preparing an antibody drug for treating melanoma, breast cancer, prostate cancer, lung cancer, ovarian cancer, thyroid cancer, liver cancer, bladder cancer, advanced gastric cancer, etc.