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|1. (WO2018121474) SINGLE-DOMAIN ANTIBODY FOR IDENTIFYING COMPLEX FORMED BY HLA-A2 MOLECULE AND RMFPNAPYL SHORT-CHAIN POLYPEPTIDE|
|Applicants:||TIMMUNE BIOTECH INC.
|Title:||SINGLE-DOMAIN ANTIBODY FOR IDENTIFYING COMPLEX FORMED BY HLA-A2 MOLECULE AND RMFPNAPYL SHORT-CHAIN POLYPEPTIDE|
Provided are single-domain antibody for identifying an HLA-A2/RMFPNAPYL complex and amino acid sequences CDR1, CDR2, and CDR3 of the antibody. Also provided is a fusion protein based on the antibody and capable of specifically identifying the HLA-A2/RMFPNAPYL complex. The antibody and the fusion protein not only identify an artificially synthesized HLA-A2/RMFPNAPYL complex, but also bind with the HLA-A2/RMFPNAPYL complex processed by combining a natural antigen and expressed on the surface of tumor cells, and can be further developed into a related tumor treating product.