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|1. (WO2018121434) ARYL HYDROCARBON RECEPTOR MODULATOR|
|Applicants:||SHENZHEN IMMUNOVA PHARMACEUTICAL CO., LTD.
|Title:||ARYL HYDROCARBON RECEPTOR MODULATOR|
Disclosed is an aryl hydrocarbon receptor modulator as represented by formula (I) and a pharmaceutically acceptable salt. R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3, formula (A), formula (B), or formula (C); two Ra are independently H, or two Ra in combination form =O or =N-W3-R1; A is unsubstituted, or a C6 to C10 aryl ring substituted with 1 to 3 R, a C2 to C10 heteroaryl ring containing 1 to 5 heteroatoms selected from N, O and S, or a 4 to 7-member non-aromatic heterocycle containing 1 to 3 heteroatoms selected from N, O and S and containing a C＝N; Q is R, or unsubstituted, or a C6 to C10 aryl ring substituted with 1 to 3 R, or a C2 to C10 heteroaryl ring containing 1 to 5 heteroatoms selected from N, O and S; and R forms RC by linking with C or forms RN by linking with N. The compound of formula (I) of the present invention can modulate the activities of AhR, thus it can be used for inhibiting the growth of cancer cells and inhibiting tumor cell metastasis and invasion.