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1. (WO2018121434) ARYL HYDROCARBON RECEPTOR MODULATOR

Pub. No.:    WO/2018/121434    International Application No.:    PCT/CN2017/118004
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: C07D 417/06
C07D 413/06
C07D 409/06
C07D 403/06
C07D 209/12
C07D 401/06
C07D 417/10
C07D 417/14
A61P 35/00
A61K 31/4245
A61K 31/4178
Applicants: SHENZHEN IMMUNOVA PHARMACEUTICAL CO., LTD.
深圳创新惠世生物科技有限公司
Inventors: YANG, Luqing
杨录青
LI, Guodong
李国栋
ZHANG, Suoming
张所明
Title: ARYL HYDROCARBON RECEPTOR MODULATOR
Abstract:
Disclosed is an aryl hydrocarbon receptor modulator as represented by formula (I) and a pharmaceutically acceptable salt. R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3, formula (A), formula (B), or formula (C); two Ra are independently H, or two Ra in combination form =O or =N-W3-R1; A is unsubstituted, or a C6 to C10 aryl ring substituted with 1 to 3 R, a C2 to C10 heteroaryl ring containing 1 to 5 heteroatoms selected from N, O and S, or a 4 to 7-member non-aromatic heterocycle containing 1 to 3 heteroatoms selected from N, O and S and containing a C=N; Q is R, or unsubstituted, or a C6 to C10 aryl ring substituted with 1 to 3 R, or a C2 to C10 heteroaryl ring containing 1 to 5 heteroatoms selected from N, O and S; and R forms RC by linking with C or forms RN by linking with N. The compound of formula (I) of the present invention can modulate the activities of AhR, thus it can be used for inhibiting the growth of cancer cells and inhibiting tumor cell metastasis and invasion.