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1. (WO2018121427) APPLICATION OF COMBINATION OF POLYETHYLENE GLYCOL AND LOCAL ANESTHETIC IN NON-NARCOTIC ANALGESIA

Pub. No.:    WO/2018/121427    International Application No.:    PCT/CN2017/117956
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: A61K 47/60
A61K 31/167
A61K 31/445
A61P 23/02
A61P 29/00
Applicants: JENKEM TECHNOLOGY CO., LTD.(TIANJIN)
天津键凯科技有限公司
Inventors: FENG, Zewang
冯泽旺
WANG, Jinliang
汪进良
XIONG, Yanli
熊艳丽
SHI, Juan
石娟
ZHAO, Xuan
赵宣
Title: APPLICATION OF COMBINATION OF POLYETHYLENE GLYCOL AND LOCAL ANESTHETIC IN NON-NARCOTIC ANALGESIA
Abstract:
An application of a combination of polyethylene glycol and a local anesthetic in non-narcotic analgesia. The local anesthetic is prepared into a prodrug or a sustained-release preparation; in the prodrug, a high molecular polymer, such as polyethylene glycol, and the local anesthetic are combined by using a covalent bond; in the sustained-release preparation, an auxiliary material having a sustained-release effect and the local anesthetic are combined by using a non-covalent bond such that the drug release speed is slow.