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1. (WO2018121400) AMIDE AND THIOAMIDE DERIVATIVES AND PREPARATION METHOD THEREFOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/121400 International Application No.: PCT/CN2017/117710
Publication Date: 05.07.2018 International Filing Date: 21.12.2017
IPC:
C07D 403/12 (2006.01) ,C07D 403/14 (2006.01) ,A61K 31/517 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
沈阳药科大学 SHENYANG PHARMACEUTICAL UNIVERSITY [CN/CN]; 中国辽宁省沈阳市 沈河区文化路103号 103 Wenhua Road, Shenhe District Shenyang, Liaoning 110016, CN
Inventors:
赵冬梅 ZHAO, Dongmei; CN
程卯生 CHENG, Maosheng; CN
郝晨洲 HAO, Chenzhou; CN
郭靖 GUO, Jing; CN
张巧玲 ZHANG, Qiaoling; CN
王凯 WANG, Kai; CN
王健 WANG, Jian; CN
黄万旭 HUANG, Wanxu; CN
李丰 LI, Feng; CN
李晓东 LI, Xiaodong; CN
Agent:
沈阳杰克知识产权代理有限公司 SHENYANG JACK INTELLECTUAL PROPERTY AGENT LTD.; 中国辽宁省沈阳市 皇姑区长江街136号1-4-13 1-4-13, No.136, Changjiang Street Huanggu District Shenyang, Liaoning 110031, CN
Priority Data:
201611223917.327.12.2016CN
Title (EN) AMIDE AND THIOAMIDE DERIVATIVES AND PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) DÉRIVÉS D'AMIDE ET DE THIOAMIDE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION
(ZH) 酰胺及硫代酰胺类衍生物及其制备方法和应用
Abstract:
(EN) The present invention falls within the technical field of medicine and relates to amide and thioamide derivatives and preparation methods therefor and the use thereof, and particularly relates to derivatives of the general formula (I) and geometrical isomers thereof or pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof and the preparation methods therefor. The derivatives have an activity as protein kinase inhibitors, especially PAK kinase inhibitors.
(FR) La présente invention se situe dans le domaine technique de la médecine et concerne des dérivés d'amide et de thioamide, leurs procédés de préparation et leur utilisation, et concerne en particulier des dérivés de formule générale (I) et des isomères géométriques de ceux-ci ou des sels, hydrates, solvates et promédicaments pharmaceutiquement acceptables de ceux-ci ainsi que leurs procédés de préparation. Les dérivés de la présente invention ont une activité en tant qu'inhibiteurs de protéine kinase, en particulier des inhibiteurs de kinase PAK.
(ZH) 本发明属于医药技术领域,涉及酰胺及硫代酰胺类衍生物及其制备方法和应用,具体涉及如通式(I)的衍生物及其几何异构体或其药学上可接受的盐、水合物、溶剂化物、前药和它们的制备方法。所述的衍生物具有作为蛋白激酶抑制剂,特别是PAK激酶抑制剂的活性。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)