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1. (WO2018121352) DRUG-LOADING INSTRUMENT AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2018/121352    International Application No.:    PCT/CN2017/117225
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Wed Dec 20 00:59:59 CET 2017
IPC: A61M 25/10
Applicants: LIFETECH SCIENTIFIC (SHENZHEN) CO., LTD
先健科技(深圳)有限公司
Inventors: LU, Jinhua
卢金华
XIE, Qizong
谢琦宗
FU, Weiguo
符伟国
YUE, Jianing
岳嘉宁
Title: DRUG-LOADING INSTRUMENT AND PREPARATION METHOD THEREFOR
Abstract:
A drug-loading instrument and a preparation method therefor, the drug-loading instrument comprising an instrument body (10) and a drug coating (12) which is disposed on a surface of the instrument body (10). The drug-loading instrument has a contracted state and an expanded state, wherein the outer diameter of the drug-loading instrument in the contracted state is smaller than the outer diameter of the drug-loading instrument in the expanded state. A protective sleeve (20) is sleeved on an outer portion of the drug-loading instrument. The protective sleeve (20) is made of a high polymer material, and the protective sleeve (20) may swell in an organic solvent. During preparation, the protective sleeve (20) first swells in a solvent to a larger inner diameter, and is then sleeved on a surface of the drug-loading instrument, after the organic solvent evaporates, the protective sleeve (20) shrinks to the original size thereof and tightly wraps the outer portion of the drug-loading instrument. Therefore, friction between an inner wall of the protective sleeve (20) and the drug coating (12) of the drug-loading instrument may be reduced, preventing the drug coating (12) or the instrument body (10) from being damaged; the drug-loading instrument may be confined to a relatively small profile outer diameter, thereby increasing the ability of the drug-loading instrument to pass through a curved body lumen or a stenotic lesion site.