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1. (WO2018121267) [1,3]THIAZOL-2-AMINE COMPOUND, APPLICATION, AND PHARMACEUTICAL COMPOSITION
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Pub. No.: WO/2018/121267 International Application No.: PCT/CN2017/116031
Publication Date: 05.07.2018 International Filing Date: 14.12.2017
IPC:
C07D 279/04 (2006.01) ,C07D 417/12 (2006.01) ,C07D 417/14 (2006.01) ,C07D 513/04 (2006.01) ,A61P 25/28 (2006.01) ,A61K 31/382 (2006.01) ,A61K 31/542 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
279
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
04
1,3-Thiazines; Hydrogenated 1,3-thiazines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
382
having six-membered rings, e.g. thioxanthenes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
542
ortho- or peri-condensed with heterocyclic ring systems
Applicants:
郑州泰基鸿诺医药股份有限公司 TETRANOV PHARMACEUTICAL CO., LTD. [CN/CN]; 中国河南省郑州市 高新技术产业开发区冬青街7号 7 Dongqing Street Hi-Tech Industries Development Zone Zhengzhou, Henan 450000, CN
Inventors:
吴豫生 WU, Yusheng; CN
梁阿朋 LIANG, Apeng; CN
牛成山 NIU, Chengshan; CN
耿阳 GENG, Yang; CN
李敬亚 LI, Jingya; CN
Agent:
深圳市威世博知识产权代理事务所(普通合伙) CHINA WISPRO INTELLECTUAL PROPERTY LLP.; 中国广东省深圳市 南山区高新区粤兴三道8号中国地质大学产学研基地中地大楼A806 Room A806 Zhongdi Building China University of Geosciences Base No. 8 Yuexing 3rd Road, High-Tech Industrial Estate, Nanshan District Shenzhen, Guangdong 518057, CN
Priority Data:
201611219244.426.12.2016CN
Title (EN) [1,3]THIAZOL-2-AMINE COMPOUND, APPLICATION, AND PHARMACEUTICAL COMPOSITION
(FR) COMPOSÉ [1,3]THIAZOL-2-AMINE, UTILISATION ET COMPOSITION PHARMACEUTIQUE
(ZH) 一种[1,3]噻嗪-2-胺类化合物及应用、药物组合物
Abstract:
(EN) A [1,3]thiazol-2-amine compound, an application, and a pharmaceutical composition. The present invention belongs to the field of BACE inhibitors. The [1,3]thiazol-2-amine compound is a compound represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof. The compound has a good inhibitory effect on BACE, and can be used in preparing a drug for treating a neurodegenerative disease, such as Alzheimer's disease.
(FR) L'invention concerne un composé [1,3]thiazol-2-amine, une utilisation et une composition pharmaceutique. L'invention concerne le domaine des inhibiteurs de BACE. Le composé [1,3]thiazol-2-amine est représenté par la formule (I) ou un sel pharmaceutiquement acceptable, un stéréoisomère, un solvate ou un promédicament de celui-ci. Le composé, selon l'invention a un bon effet inhibiteur sur BACE, et peut être utilisé dans la préparation d'un médicament pour le traitement d'une maladie neurodégénérative, telle que la maladie d'Alzheimer.
(ZH) 一种[1,3]噻嗪-2-胺类化合物及应用和药物组合物,属于BACE抑制剂领域。[1,3]噻嗪-2-胺类化合物为式(Ⅰ)所示的化合物,或其药学上可接受的盐、立体异构体、溶剂化物或前药。所述化合物对BACE具有良好抑制作用,可用于制备治疗阿兹海默症等神经退行性疾病的药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)