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1. (WO2018121235) PEPTIDE FOR REPAIRING CARTILAGE AND TREATING OSTEOARTHRITIS

Pub. No.:    WO/2018/121235    International Application No.:    PCT/CN2017/115532
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Wed Dec 13 00:59:59 CET 2017
IPC: C07K 14/51
A61K 38/18
A61P 19/02
A61P 19/08
A61P 29/00
Applicants: LINK HEALTH GROUP
广州领晟医疗科技有限公司
Inventors: SONG, Yan
宋燕
XU, Yuansheng
许元生
LU, Xiaoyu
卢肖宇
Title: PEPTIDE FOR REPAIRING CARTILAGE AND TREATING OSTEOARTHRITIS
Abstract:
Provided is a BM23 peptide obtained by mutating and modifying BMP-2. The BM23 peptide has improved stability and duration of in vivo efficacy relative to BMP-2, can promote the differentiation of bone marrow mesenchymal stem cells into chondrocytes and promote the proliferative activity of chondrocytes, and can be used for cartilage repair and/or treatment of osteoarthritis.