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1. (WO2018121129) CARBONYL REDUCTASE OLIGOMER AND USE THEREOF IN SYNTHESIS OF CHIRAL ALCOHOL
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/121129 International Application No.: PCT/CN2017/112152
Publication Date: 05.07.2018 International Filing Date: 21.11.2017
IPC:
C12N 9/02 (2006.01) ,C12P 7/22 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
22
aromatic
Applicants: JIANGNAN UNIVERSITY[CN/CN]; Xiaoyue Geng F7 south building, No.898 tongsha road Wuxi, Jiangsu 214122, CN
Inventors: ZHANG, Rongzhen; CN
XU, Yan; CN
Agent: HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO.,LTD.; Xiaoyue Geng Room E501,Building 18,Science and technology 1st street No.99,District Songbei Harbin, Heilongjiang 150028, CN
Priority Data:
201611250627.830.12.2016CN
Title (EN) CARBONYL REDUCTASE OLIGOMER AND USE THEREOF IN SYNTHESIS OF CHIRAL ALCOHOL
(FR) OLIGOMÈRE DE CARBONYL RÉDUCTASE ET SON UTILISATION DANS LA SYNTHÈSE D'ALCOOL CHIRAL
(ZH) 羰基还原酶寡聚体及其在手性醇合成中的应用
Abstract:
(EN) Provided is a carbonyl reductase oligomer and use thereof in synthesis of a chiral alcohol. A (S)-carbonyl reductase introduced with a SrtA recognition sequence is purified, meanwhile, a purified SrtA enzyme is obtained by means of purification. By employing a coupling reaction mediated by SrtA, the (S)-carbonyl reductase oligomer is obtained. By using the separated oligomer as a catalyst and using 2-hydroxyacetophenone as a substrate, a product (S)-phenyl glycol is prepared.
(FR) L'invention concerne un oligomère de carbonyle réductase et son utilisation dans la synthèse d'un alcool chiral. Une (S)-carbonyle réductase dans laquelle est introduite une séquence de reconnaissance SrtA est purifiée, permettant d'obtenir une enzyme SrtA purifiée par purification. En employant une réaction de couplage médiée par SrtA, l'oligomère de (S)-carbonyl réductase est obtenu. En utilisant l'oligomère séparé en tant que catalyseur et en utilisant de la 2-hydroxyacétophénone en tant que substrat, un produit (S)-phényle glycol est préparé.
(ZH) 提供一种羰基还原酶寡聚体及其在手性醇合成中的应用。将引入SrtA识别序列的(S)-羰基还原酶进行纯化,同时纯化得到SrtA纯酶,利用SrtA介导的连接反应,得到(S)-羰基还原酶寡聚体;以分离得到的寡聚体为催化剂,2-羟基苯乙酮为底物,制备产物(S)-苯基乙二醇。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)