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1. (WO2018120777) RIVAROXABAN SELF-EMULSIFYING PREPARATION AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/120777 International Application No.: PCT/CN2017/093298
Publication Date: 05.07.2018 International Filing Date: 18.07.2017
IPC:
A61K 9/107 (2006.01) ,A61K 31/5377 (2006.01) ,A61K 47/44 (2017.01) ,A61K 47/14 (2006.01) ,A61K 9/20 (2006.01) ,A61P 7/02 (2006.01) ,A61P 9/14 (2006.01) ,A61P 9/10 (2006.01) ,A61P 11/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
44
Oils, fats or waxes according to more than one of groups A61K47/02-A61K47/42109
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
14
Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants: HYBIO PHARMACEUTICAL CO., LTD.[CN/CN]; 4th Floor of Office Building Hybio Medicine Park, Shenzhen Hi-tech Industrial Park, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors: YAN, Xieguo; CN
ZHANG, Weiming; CN
TAO, Anjin; CN
YUAN, Jiancheng; CN
Agent: SHENPAT INTELLECTUAL PROPERTY AGENCY; Room 1521 West Block, Guomao Building Shenzhen, Guangdong 518014, CN
Priority Data:
201611220383.926.12.2016CN
Title (EN) RIVAROXABAN SELF-EMULSIFYING PREPARATION AND PREPARATION METHOD THEREFOR
(FR) PRÉPARATION AUTO-ÉMULSIFIANTE DE RIVAROXABAN ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种利伐沙班自乳化制剂及其制备方法
Abstract:
(EN) Provided are a rivaroxaban self-emulsifying preparation and a preparation method therefor, wherein the preparation comprises by mass percentage, 1 to 13% of rivaroxaban, 5 to 50% of oil phase, 20 to 70% of emulsifier, 0 - 50% of the coemulsifier; the preparation method therefor comprises mixing the oil phase, the emulsifier and the coemulsifier uniformly, and then mixing the mixture with rivaroxaban to obtain the rivaroxaban self-emulsifying preparation.
(FR) L'invention concerne une préparation auto-émulsifiante de rivaroxaban et son procédé de préparation, la préparation comprenant en pourcentage en masse, 1 à 13 % de rivaroxaban, 5 à 50 % de phase huileuse, 20 à 70 % d'émulsifiant, 0 à 50 % du co-émulsifiant; le procédé de préparation de celle-ci comprend le mélange de la phase huileuse, de l'émulsifiant et du co-émulsifiant de manière uniforme, et ensuite le mélange du mélange avec du rivaroxaban pour obtenir la préparation auto-émulsifiante de rivaroxaban.
(ZH) 一种利伐沙班自乳化制剂及其制备方法,所述制剂按质量百分比计,包括1-13%的利伐沙班,5-50%的油相,20-70%的乳化剂,0-50%的助乳化剂;该制剂的制备方法包括将油相、乳化剂、助乳化剂混合均匀,然后与利伐沙班混合均匀得到利伐沙班自乳化制剂。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)