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1. (WO2018120094) METHOD FOR PREPARING 2-(CYCLOHEXENYLENE) MALONIC ACID DERIVATIVE AND USE THEREOF

Pub. No.:    WO/2018/120094    International Application No.:    PCT/CN2016/113671
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 31 00:59:59 CET 2016
IPC: C07C 69/38
C07C 67/22
C07C 13/20
A01N 43/90
A01P 13/00
Applicants: ORIENTAL(LUZHOU) AGROCHEMICALS. CO., LTD.
泸州东方农化有限公司
Inventors: SUN, Yinwei
孙殷卫
WANG, Zhongyuan
王忠元
ZHANG, Pan
张盼
CHEN, Bangchi
陈邦池
Title: METHOD FOR PREPARING 2-(CYCLOHEXENYLENE) MALONIC ACID DERIVATIVE AND USE THEREOF
Abstract:
Provided are a method for preparing a 2-(cyclohexenylene) malonic acid derivative and the use thereof. In the method, an olefin and a 2-substituted malonic acid derivative are used as raw materials and are subjected to a cyclization reaction in the presence of a catalyst so as to give the 2-(cyclohexenylene) malonic acid derivative. The method has the following features: (1) same is capable of synthesizing a 2-(2,6-disubstituted cyclohexenylene) malonic acid derivative very efficiently; and (2) same has a high reaction yield, mild conditions, less of the three wastes, and is favourable for industrial production. More importantly, the 2-(cyclohexenylene) malonic acid derivative can be used in organic synthesis, and in particular, can be used in the synthesis of 2-aryl malonic acid derivatives and the corresponding drugs, such as the herbicide pinoxaden.