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|1. (WO2018120094) METHOD FOR PREPARING 2-(CYCLOHEXENYLENE) MALONIC ACID DERIVATIVE AND USE THEREOF|
|Applicants:||ORIENTAL(LUZHOU) AGROCHEMICALS. CO., LTD.
|Title:||METHOD FOR PREPARING 2-(CYCLOHEXENYLENE) MALONIC ACID DERIVATIVE AND USE THEREOF|
Provided are a method for preparing a 2-(cyclohexenylene) malonic acid derivative and the use thereof. In the method, an olefin and a 2-substituted malonic acid derivative are used as raw materials and are subjected to a cyclization reaction in the presence of a catalyst so as to give the 2-(cyclohexenylene) malonic acid derivative. The method has the following features: (1) same is capable of synthesizing a 2-(2,6-disubstituted cyclohexenylene) malonic acid derivative very efficiently; and (2) same has a high reaction yield, mild conditions, less of the three wastes, and is favourable for industrial production. More importantly, the 2-(cyclohexenylene) malonic acid derivative can be used in organic synthesis, and in particular, can be used in the synthesis of 2-aryl malonic acid derivatives and the corresponding drugs, such as the herbicide pinoxaden.