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1. (WO2018119518) RP215 CHIMERIC ANTIGEN RECEPTOR CONSTRUCT AND METHODS OF MAKING AND USING SAME

Pub. No.:    WO/2018/119518    International Application No.:    PCT/CA2017/051600
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: C12N 15/85
A61K 35/17
A61P 35/00
C07K 14/705
C07K 14/28
C07K 16/30
C07K 16/46
C12N 15/13
C12N 15/19
C12N 15/62
C12N 15/86
C12N 5/0783
C12N 5/10
C07K 19/00
Applicants: LEE, Chi-Yu Gregory
Inventors: LEE, Chi-Yu Gregory
Title: RP215 CHIMERIC ANTIGEN RECEPTOR CONSTRUCT AND METHODS OF MAKING AND USING SAME
Abstract:
A chimeric antigen receptor (CAR) having an antigen binding domain capable of binding to CA215. The antigen binding domain can have a binding affinity and specificity similar to the RP215 antibody. Methods of making and using such CARs are provided. The CARs can be used to treat cancer.