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1. WO2018115383 - BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS

Publication Number WO/2018/115383
Publication Date 28.06.2018
International Application No. PCT/EP2017/084271
International Filing Date 21.12.2017
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
C07D 487/04 (2006.01)
A61K 31/519 (2006.01)
A61P 37/00 (2006.01)
A61P 11/00 (2006.01)
CPC
A61K 31/519
A61K 45/06
A61K 9/0073
A61P 11/00
A61P 11/06
A61P 37/00
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A 43122 PARMA, IT
Inventors
  • ACCETTA, Alessandro; IT
  • RANCATI, Fabio; IT
  • CAPELLI, Anna Maria; IT
  • CLARK, David Edward; IT
  • TISSELLI, Patrizia; IT
  • EDWARDS, Christine; IT
  • BHALAY, Gurdip; IT
Agents
  • MINOJA, Fabrizio; IT
Priority Data
16205661.821.12.2016EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS
(FR) DÉRIVÉS DE DIHYDROPYRIMIDINE-CARBOXAMIDE BICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE RHO-KINASE
Abstract
(EN)
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
(FR)
L'invention concerne des composés de formule (I) inhibant la Rho Kinase qui sont des dérivés de dihydropyrimidine-carboxamide bicycliques, ainsi que des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Particulièrement, les composés de l'invention peuvent être utiles dans le traitement de nombreux troubles associés à des mécanismes enzymatiques de ROCK, tels que des maladies pulmonaires y compris l'asthme, la broncho-pneumopathie chronique obstructive (COPD), la fibrose pulmonaire idiopathique (IPF) et l'hypertension artérielle pulmonaire (HTAP).
Also published as
EP2017828752
JP2019527305
MXMX/a/2019/005526
RU2019121944
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