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1. (WO2018108185) GROUP OF PEPTIDES HAVING ANALGESIC EFFECT, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Pub. No.:    WO/2018/108185    International Application No.:    PCT/CN2017/116992
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Tue Dec 19 00:59:59 CET 2017
IPC: C07K 7/06
A61K 38/08
Applicants: TANG, Qiongyao
唐琼瑶
XUZHOU MEDICAL UNIVERSITY
徐州医科大学
THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY
西南医科大学附属医院
Inventors: TANG, Qiongyao
唐琼瑶
TANG, Qiongyao
唐琼瑶
ZHANG, Zhe
张赭
TANG, Mingxi
唐明希
Title: GROUP OF PEPTIDES HAVING ANALGESIC EFFECT, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Abstract:
Disclosed are a group of peptides having an analgesic effect, and a pharmaceutical composition and the use thereof, wherein the peptides have the amino acid sequences as shown in SEQ ID No. 1 or SEQ ID No. 2 in the sequence listing, or pharmaceutically acceptable salts thereof. Also disclosed are polypeptides or pharmaceutically acceptable salts thereof, these still having an analgesic effect after one or more amino acids are deleted, substituted, or added in the amino acid sequences as shown in SEQ ID No. 1 or SEQ ID No. 2 in the sequence listing on the basis of cysteines being present at the N-terminus and C-terminus thereof. Polypeptides are formed after the deletion, substitution, or addition of one or more amino acids in Loop 3 of GsMTx-4, and then, the polypeptides are screened for a polypeptide having an analgesic effect. A short-chain series of polypeptides having an analgesic effect is confirmed by means of test results of the polypeptides with regard to a rat nociceptive pain model.