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1. (WO2018108167) CDK4/6 INHIBITOR

Pub. No.:    WO/2018/108167    International Application No.:    PCT/CN2017/116611
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Sat Dec 16 00:59:59 CET 2017
IPC: C07D 471/04
C07D 519/00
A61K 31/4965
A61K 31/4375
A61P 35/00
Applicants: CSTONE PHARMACEUTICALS
基石药业
MEDSHINE DISCOVERY INC.
南京明德新药研发股份有限公司
Inventors: XU, Zhaobing
徐招兵
HU, Lihong
胡利红
DING, Charles Z.
丁照中
CHEN, Shuhui
陈曙辉
Title: CDK4/6 INHIBITOR
Abstract:
Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers.