Search International and National Patent Collections

1. (WO2018108157) RUCAPARIB ORAL SUSTAINED/CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND USE THEREOF

Pub. No.:    WO/2018/108157    International Application No.:    PCT/CN2017/116494
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Sat Dec 16 00:59:59 CET 2017
IPC: A61K 31/551
A61K 9/22
A61K 9/52
A61P 35/00
Applicants: SCIENCE RAINBOW BIOPHARMA CO. LTD
苏州苏融生物医药有限公司
Inventors: GAN, Yong
甘勇
MENG, Bingxue
孟冰雪
GUO, Shiyan
郭仕艳
ZHU, Chunliu
朱春柳
Title: RUCAPARIB ORAL SUSTAINED/CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND USE THEREOF
Abstract:
Disclosed is a rucaparib oral sustained/controlled release pharmaceutical composition, comprising rucaparib in a form for improved dissolution and a matrix polymer for regulating the release rate. The in vivo absorption behaviour, plasma drug concentration and PARP enzyme inhibitory level of the pharmaceutical composition can be controlled, thereby improving the drug load and/or oral absorption and/or bioavailability and/or plasma drug concentration control and/or enzyme inhibitory level control of the rucaparib, and the pharmaceutical composition can be used as the only preparation or in combination with other therapies for treating cancers.