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|1. (WO2018108157) RUCAPARIB ORAL SUSTAINED/CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND USE THEREOF|
|Applicants:||SCIENCE RAINBOW BIOPHARMA CO. LTD
|Title:||RUCAPARIB ORAL SUSTAINED/CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND USE THEREOF|
Disclosed is a rucaparib oral sustained/controlled release pharmaceutical composition, comprising rucaparib in a form for improved dissolution and a matrix polymer for regulating the release rate. The in vivo absorption behaviour, plasma drug concentration and PARP enzyme inhibitory level of the pharmaceutical composition can be controlled, thereby improving the drug load and/or oral absorption and/or bioavailability and/or plasma drug concentration control and/or enzyme inhibitory level control of the rucaparib, and the pharmaceutical composition can be used as the only preparation or in combination with other therapies for treating cancers.