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1. (WO2018108084) COMPOUND CONTAINING TRICYCLIC HETEROARYL GROUP

Pub. No.:    WO/2018/108084    International Application No.:    PCT/CN2017/115756
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Wed Dec 13 00:59:59 CET 2017
IPC: C07D 498/04
C07D 519/00
A61K 31/5383
A61P 35/00
A61P 1/16
A61P 11/00
Applicants: HANGZHOU INNOGATE PHARMA CO., LTD.
杭州英创医药科技有限公司
Inventors: ZHANG, Hancheng
张汉承
LIU, Shifeng
刘世峰
YE, Xiangyang
叶向阳
Title: COMPOUND CONTAINING TRICYCLIC HETEROARYL GROUP
Abstract:
Provided is a compound containing a tricyclic heteroaryl group. Specifically, provided are a compound (the definitions of groups are as stated in the description) having a structure as shown in formula (I), a pharmaceutical composition containing the compound of formula (I), and the compound, and isotopic derivatives, chiral isomers, allosterisms, different salts, prodrugs, formulations, etc. The present invention can effectively inhibit protein kinases (such as EGFR, FAK, SYK, FLT-3, Axl, CDK, and JAK), so that many related diseases, such as different tumors, nonalcoholic steatohepatitis (NASH), and idiopathic pulmonary fibrosis (IPF) can be treated.