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1. (WO2018107388) HUMAN GENETIC MARKERS ASSOCIATED WITH RESPONSE TO TREATMENTS THAT TARGET CLOSTRIDIUM DIFFICILE TOXIN B

Pub. No.:    WO/2018/107388    International Application No.:    PCT/CN2016/109900
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Thu Dec 15 00:59:59 CET 2016
IPC: C12Q 1/68
C07K 16/18
A61K 39/40
A61P 31/04
Applicants: MERCK SHARP & DOHME CORP.
BEIJING GENOMICS INSTITUTE AT SHENZHEN
SHAW, Peter M.
MEHROTRA, Devan V.
BLANCHARD, Rebecca L.
SHEN, Judong
MOGG, Robin
DORR, Mary Beth
LI, Junhua
XU, Xun
Inventors: SHAW, Peter M.
MEHROTRA, Devan V.
BLANCHARD, Rebecca L.
SHEN, Judong
MOGG, Robin
DORR, Mary Beth
LI, Junhua
XU, Xun
Title: HUMAN GENETIC MARKERS ASSOCIATED WITH RESPONSE TO TREATMENTS THAT TARGET CLOSTRIDIUM DIFFICILE TOXIN B
Abstract:
The present invention provides genetic markers on human chromosome 6 that are associated with a beneficial response to a treatment that targets Clostridium difficile (C. difficile) toxin B (TcdB), e.g. a TcdB antibody. These TcdB treatment response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment with a treatment that targets TcdB in methods of treating patients having a disease susceptible to treatment with a TcdB antibody, and in methods for selecting the most appropriate therapy for such patients. The invention also provides antibodies, drug products, and kits useful with the TcdB Treatment response markers of the invention.