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1. (WO2018107294) DNA METHYLATION MARKERS FOR NEUROPSYCHIATRIC DISORDERS AND METHODS, USES AND KITS THEREOF

Pub. No.:    WO/2018/107294    International Application No.:    PCT/CA2017/051516
Publication Date: Fri Jun 22 01:59:59 CEST 2018 International Filing Date: Fri Dec 15 00:59:59 CET 2017
IPC: C12Q 1/68
C12Q 1/6809
G01N 33/48
Applicants: THE HOSPITAL FOR SICK CHILDREN
Inventors: WEKSBERG, Rosanna
CHOUFANI, Sanaa
BUTCHER, Darci
SIU, Michelle
Title: DNA METHYLATION MARKERS FOR NEUROPSYCHIATRIC DISORDERS AND METHODS, USES AND KITS THEREOF
Abstract:
The present disclosure provides epigenetic signatures, comprising genomic CpG dinucleotide sequences, genes, and/or genomic regions, which are differentially methylated in individuals with pathogenic copy number variants or a pathogenic mutation that are associated with a neuropsychiatric disorder (ND) or increased likelihood of an ND, and their use in methods and kits for detecting and/or screening for ND, or the likelihood of ND.