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1. (WO2018107167) PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE

Pub. No.:    WO/2018/107167    International Application No.:    PCT/US2017/065622
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Tue Dec 12 00:59:59 CET 2017
IPC: C07C 237/06
C07C 237/12
A61P 29/00
A61K 31/167
A61K 31/216
A61K 31/4025
A61K 31/4178
A61K 31/4439
C07D 403/12
C07D 401/12
C07D 207/325
Applicants: CELTAXSYS, INC.
Inventors: ROINESTAD, Kurt
GUILFORD, William
KIRKLAND, Tom
BHATT, Lopa
SPRINGMAN, Eric
Title: PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
Abstract:
This present disclosure is directed to compounds of formula (I): (I) where R1a, R1b, R1c, R1d, R1e, R3, R4a, R4b, R4c, R4d, R6, R7, and R8 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided.