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1. (WO2018107146) METHODS AND COMPOSITIONS FOR TREATMENT OF BRAF MUTANT CANCERS

Pub. No.:    WO/2018/107146    International Application No.:    PCT/US2017/065532
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Tue Dec 12 00:59:59 CET 2017
IPC: A61K 31/06
A61K 31/437
A61K 31/44
A61K 31/506
A61K 31/519
A61K 31/65
Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: LITO, Piro
Title: METHODS AND COMPOSITIONS FOR TREATMENT OF BRAF MUTANT CANCERS
Abstract:
The present invention provides various compositions and methods useful for the treatment of BRAF-mutant tumors, such as BRAFV600E-mutant tumors. In some embodiments such methods involve administration of three active agents - a RAF inhibitor, a MEK inhibitor, and an ERK inhibitor. The present invention also provides novel intermittent dosing regimens for these three active agents that maintain maximal anti-tumor efficacy while also minimizing toxicity.