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1. (WO2018107134) CHIMERIC CHLOROTOXIN RECEPTORS

Pub. No.:    WO/2018/107134    International Application No.:    PCT/US2017/065488
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sun Dec 10 00:59:59 CET 2017
IPC: C07K 16/18
C07K 16/00
A61K 47/68
Applicants: THE UAB RESEARCH FOUNDATION
Inventors: LAMB, Lawrence S., Jr.
DI STASI, Antonio
GILLESPIE, Yancey, G.
PEREBOEVA, Larisa
Title: CHIMERIC CHLOROTOXIN RECEPTORS
Abstract:
The invention provides chimeric antigen receptor(s) (CAR(s)) that comprise a fusion protein of CTX or any functional variant thereof or a CTX-like peptide or any functional variant thereof as the extracellular antigen recognition moiety of the CAR. CAR(s) comprising CTX, a CTX-like peptide or functional variants of the foregoing are collectively referred to herein as "CTX-CAR(s)." Such CTX-CAR(s) may furher comprise additional moieties or domains in the extracellular domain, a transmembrane domain and at least one intracellular! signaling domain. SUch CTX-CAR(s) may be expressed in a host cell, such as, but not limited to, an immune effector cell. The prsent invention also provides methods of treatment (such as, for example, methods for treating cancer) by providing to the patient in need thereof immune effector cells that are engineered to express a CTX-CAR described herein.