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1. (WO2018107131) METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME

Pub. No.:    WO/2018/107131    International Application No.:    PCT/US2017/065481
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sun Dec 10 00:59:59 CET 2017
IPC: C07D 401/12
C07F 9/59
Applicants: KEMPHARM, INC.
Inventors: MICKLE, Travis
GUENTHER, Sven M.
CHI, Gouchen
Title: METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME
Abstract:
The present technology is directed to d-threo-methylphenidate conjugates and a composition comprising d-threo-methylphenidate conjugated to nicotinoyl-L-serine, or salt thereof. The present technology also relates to a composition comprising at least one conjugate of d-methylphenidate having at least two or more chiral centers. The composition is optically active. The present technology additionally relates to oral formulations and pharmaceutical kits comprising at least one d-threo-methylphenidate conjugate. The pharmaceutical kit may comprise a specified amount of individual doses in a package. Each individual dose in the package may contain a pharmaceutically effective amount of a conjugate of d-threo methylphenidate.