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1. (WO2018107112) QUINOLONE-BASED COMPOUNDS WITH ANTICANCER ACTIVITY

Pub. No.:    WO/2018/107112    International Application No.:    PCT/US2017/065448
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: C07D 291/04
C07D 215/56
C07D 295/155
Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION
REGENTS OF THE UNIVERSITY OF MINNESOTA
KERNS, Robert J.
TOWLE, Tyrell
HIASA, Hiroshi
Inventors: KERNS, Robert J.
TOWLE, Tyrell
HIASA, Hiroshi
Title: QUINOLONE-BASED COMPOUNDS WITH ANTICANCER ACTIVITY
Abstract:
Embodiments are directed to compounds of the formulae (I), (Ia), (Ib), (II), (IIa) (III), (IV), (V), and (VI); methods for treating cancer with one or more compounds of the formulae (I), (Ia), (Ib), (II), (IIa); (III), (IV), (V), and (VI); and methods for inhibiting a human topoisomerase with one or more compounds of the formulae (I), (Ia), (Ib), (II), (IIa); (III), (IV), (V), and (VI).