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1. (WO2018107096) STAUFEN1 AGENTS AND ASSOCIATED METHODS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/107096    International Application No.:    PCT/US2017/065421
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
IPC:
C07H 21/02 (2006.01), C07H 21/04 (2006.01), G01N 33/50 (2006.01)
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapeen Drive, Suite 310 Salt Lake City, Utah 84108 (US)
Inventors: PULST, Stefan M.; (US)
Agent: OSBORNE, David W.; (US)
Priority Data:
62/431,757 08.12.2016 US
Title (EN) STAUFEN1 AGENTS AND ASSOCIATED METHODS
(FR) AGENTS DE LA STAUFEN1 ET PROCÉDÉS ASSOCIÉS
Abstract: front page image
(EN)Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.
(FR)L'invention concerne des méthodes de réduction de la dérégulation du métabolisme de l'ARN associé à la Staufen1 qui peuvent comprendre l'introduction d'une certaine quantité d'un agent de régulation de la Staufen1 dans une cellule cible, suffisant pour réduire la dérégulation. Des compositions thérapeutiques permettant de traiter une affection neurodégénérative associée à une dérégulation induite par la Staufen1 du métabolisme de l'ARN peuvent comprendre une quantité thérapeutiquement efficace d'un agent de régulation de la Staufen1 et un véhicule pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)