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1. (WO2018107059) METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND RISK OF PROGRESSION TO ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/107059    International Application No.:    PCT/US2017/065367
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
IPC:
A61B 5/00 (2006.01), C07K 14/47 (2006.01), C12Q 1/68 (2018.01), G01N 33/50 (2006.01), G01N 33/68 (2006.01)
Applicants: LOMA LINDA UNIVERSITY HEALTH [US/US]; 11234 Anderson Street Loma Linda, California 92354 (US)
Inventors: SORIANO, Salvador; (US).
CASTELLO, Michael; (US)
Agent: FLANAGAN, Lisa, D.; (US).
APPLE, Randolph T.; (US)
Priority Data:
62/432,091 09.12.2016 US
Title (EN) METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND RISK OF PROGRESSION TO ALZHEIMER'S DISEASE
(FR) PROCÉDÉS DE DIAGNOSTIC DE LA MALADIE D'ALZHEIMER ET DU RISQUE D'ÉVOLUTION EN MALADIE D'ALZHEIMER
Abstract: front page image
(EN)In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.
(FR)La présente invention concerne, selon un aspect, des procédés de diagnostic de la maladie d'Alzheimer d'un sujet et de pronostic du risque d'évolution en maladie d'Alzheimer chez un sujet. Selon certains modes de réalisation, le procédé consiste à déterminer le niveau d'expression de la rhotékine 2 (RTKN2) et/ou le niveau d'expression de la Ser/Thr kinase 4 associée aux microtubules (MAST4) et/ou le niveau de liaison du facteur de transcription FOXO1 (forkhead box O1) au promoteur du gène RTKN2 et/ou le niveau de liaison de la protéine précurseur d'amyloïde (APP) au promoteur du gène MAST4 dans un échantillon provenant du sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)