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1. (WO2018107049) BONE-PROMOTING THERMORESPONSIVE MACROMOLECULES

Pub. No.:    WO/2018/107049    International Application No.:    PCT/US2017/065352
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: A61K 31/33
A61L 15/18
A61L 31/16
Applicants: NORTHWESTERN UNIVERSITY
Inventors: AMEER, Guillermo A.
MOROCHNIK, Simona
Title: BONE-PROMOTING THERMORESPONSIVE MACROMOLECULES
Abstract:
Provided herein are injectable, thermoresponsive hydrogels that are liquid at room temperature, provide a carrier material, and gel at body temperature to allow for controlled release. In particular, PPCN-based hydrogels are provided with therapeutic agents (e.g., drugs, ions, etc.) incorporated within or appended thereto, and methods of preparation and use thereof, for example, for the promotion of bone formation/repair and/or the treatment of bone diseases.