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1. (WO2018107040) 1-(2-FLUOROPHENYL)-N-[1-(2-FLUORO-4-PYRIDYL)PYRAZOL-3-YL]CYCLOPROPANECARBOXAMIDE, ITS SOLID FORMS AND PHARMACEUTICAL USES THEREOF
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Pub. No.:    WO/2018/107040    International Application No.:    PCT/US2017/065335
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
IPC:
C07D 401/04 (2006.01), A61P 25/00 (2006.01), A61P 25/28 (2006.01), A61K 31/4439 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 50 Northern Avenue Boston, MA 02210 (US)
Inventors: COURT, John, J.; (US)
Agent: NEY, Joshua, E.; (US).
BOUDREAUX, William, R.; (US)
Priority Data:
62/432,499 09.12.2016 US
Title (EN) 1-(2-FLUOROPHENYL)-N-[1-(2-FLUORO-4-PYRIDYL)PYRAZOL-3-YL]CYCLOPROPANECARBOXAMIDE, ITS SOLID FORMS AND PHARMACEUTICAL USES THEREOF
(FR) 1-(2-FLUOROPHÉNYL)-N-[1-(2-FLUORO-4-PYRIDYL)PYRAZOL-3-YL]CYCLOPROPANECARBOXAMIDE, SES FORMES SOLIDES ET LEURS UTILISATIONS PHARMACEUTIQUES
Abstract: front page image
(EN)Disclosed is a 1,3 -substituted pyrazole compound in solid form, pharmaceutical compositions thereof, useful for reduction of very long chain fatty acid levels and for treating various disease, disorders and conditions, such as adrenoleukodystrophy (ALD).
(FR)L'invention concerne un composé pyrazole à substitution en position 1 et 3 sous forme solide, des compositions pharmaceutiques de celui-ci, utile pour la réduction des niveaux d'acides gras à chaîne très longue et pour le traitement de diverses maladies, troubles et états pathologiques, tels que l'adrénoleucodystrophie (ALD).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)