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|1. (WO2018107013) DUAL RANGE CARDIAC TROPONIN IMMUNOASSAY DEVICES AND METHODS USING IMMUNOSENSOR AND MAGNETIC IMMUNOSENSOR|
|Applicants:||ABBOTT POINT OF CARE INC.
|Inventors:||HU, Jing Hua
VIRTANEN, Antti Leo Oskari
POTTER, Eric Edward
SMITH, James T.K.
MILLER, Cary James
CAMPBELL, John Lewis Emerson
MOSS, Adam Roger
|Title:||DUAL RANGE CARDIAC TROPONIN IMMUNOASSAY DEVICES AND METHODS USING IMMUNOSENSOR AND MAGNETIC IMMUNOSENSOR|
The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first immunosensor including an immobilized layer of capture antibodies configured to bind to a first complex of signal antibodies and cardiac troponin such that a second complex of the first complex and the immobilized layer of capture antibodies is localized on or near the first immunosensor. The device further includes a second immunosensor having a magnetic field disposed locally around the second immunosensor. The magnetic field is configured to attract magnetic beads such that a third complex of the first complex and capture antibodies immobilized on the magnetic beads is localized on or near the second immunosensor sensor.