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1. (WO2018107013) DUAL RANGE CARDIAC TROPONIN IMMUNOASSAY DEVICES AND METHODS USING IMMUNOSENSOR AND MAGNETIC IMMUNOSENSOR

Pub. No.:    WO/2018/107013    International Application No.:    PCT/US2017/065284
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: G01N 33/543
G01N 33/68
G01N 27/74
Applicants: ABBOTT POINT OF CARE INC.
Inventors: HU, Jing Hua
VIRTANEN, Antti Leo Oskari
POTTER, Eric Edward
SMITH, James T.K.
MILLER, Cary James
CAMPBELL, John Lewis Emerson
MOSS, Adam Roger
Title: DUAL RANGE CARDIAC TROPONIN IMMUNOASSAY DEVICES AND METHODS USING IMMUNOSENSOR AND MAGNETIC IMMUNOSENSOR
Abstract:
The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first immunosensor including an immobilized layer of capture antibodies configured to bind to a first complex of signal antibodies and cardiac troponin such that a second complex of the first complex and the immobilized layer of capture antibodies is localized on or near the first immunosensor. The device further includes a second immunosensor having a magnetic field disposed locally around the second immunosensor. The magnetic field is configured to attract magnetic beads such that a third complex of the first complex and capture antibodies immobilized on the magnetic beads is localized on or near the second immunosensor sensor.