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1. (WO2018106993) TLR9-BINDING CHIMERIC ANTIGEN RECEPTORS

Pub. No.:    WO/2018/106993    International Application No.:    PCT/US2017/065249
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: A61K 39/395
A61P 35/00
C07K 14/705
C07K 16/28
Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC.
Inventors: ABATE DAGA, Daniel
LIST, Alan F.
WEI, Sheng
Title: TLR9-BINDING CHIMERIC ANTIGEN RECEPTORS
Abstract:
Disclosed herein are chimeric antigen receptor (CAR) polypeptides that can be used with adoptive cell transfer to target and kill cancer cells that express TLR9 on their surface. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a TLR9-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.