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1. (WO2018106992) MULTIFUNCTIONAL RNA NANOPARTICLES AND METHODS FOR TREATING CANCER AND THERAPEUTIC RESISTANT CANCER
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Pub. No.: WO/2018/106992 International Application No.: PCT/US2017/065248
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
IPC:
C12N 15/00 (2006.01) ,A61K 47/69 (2017.01) ,C12N 15/113 (2010.01) ,C12N 15/115 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
[IPC code unknown for A61K 47/69]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
115
Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
Applicants:
UNIVERSITY OF CINCINNATI [US/US]; 51 Goodman Drive Suite 240 Cincinnati, Ohio 45221, US
Inventors:
ZHANG, Xiaoting; US
GUO, Peixuan; US
Agent:
EVERETT, Denise M.; US
LORENTZ, Joshua A.; US
BEYER, James; US
BONNER, Anthony F.; US
ELSWICK, Christopher; US
LIVINGSTON, Jennifer L.; US
TENT, Brian; US
Priority Data:
62/431,64008.12.2016US
Title (EN) MULTIFUNCTIONAL RNA NANOPARTICLES AND METHODS FOR TREATING CANCER AND THERAPEUTIC RESISTANT CANCER
(FR) NANOPARTICULES D'ARN MULTIFONCTIONNELLES ET PROCÉDÉS DE TRAITEMENT DU CANCER ET D'UN CANCER RÉSISTANT À UNE THÉRAPIE
Abstract:
(EN) RNA nanoparticles functionalized with a HER2-targeting RNA aptamer and at least one MED1 siRNA for targeted delivery of MED1 siRNA to human cancer cells via human epidermal growth factor receptor 2 (HER2) receptors, pharmaceutical compositions of the inventive RNA nanoparticles, and methods for treating breast, HER2-implicated cancers, and in particular therapeutic-resistant cancer such as tamoxifen-resistant breast cancer, by administering pharmaceutical compositions of the inventive RNA nanoparticles.
(FR) L'invention concerne des nanoparticules d'ARN fonctionnalisées avec un aptamère d'ARN ciblant HER2 et au moins un ARNsi de MED1 pour une administration ciblée d'ARNsi de MED1 à des cellules cancéreuses humaines par l'intermédiaire du récepteur du facteur de croissance épidermique humain 2 (HER2), des compositions pharmaceutiques des nanoparticules d'ARN de l'invention, et des procédés pour traiter un cancer du sein dans lequel HER2 est impliqué, et en particulier un cancer résistant à une thérapie tel que le cancer du sein résistant au tamoxifène, par l'administration de compositions pharmaceutiques des nanoparticules d'ARN de l'invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)