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1. (WO2018106956) IL-1RA CDNAs

Pub. No.:    WO/2018/106956    International Application No.:    PCT/US2017/065173
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 08 00:59:59 CET 2017
IPC: C07K 14/54
C12N 15/09
C12N 15/63
C12P 21/04
Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
Inventors: GHIVIZZANI, Steven C.
Title: IL-1RA CDNAs
Abstract:
The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.