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1. (WO2018106922) N-ARYLATED ANALOGUES AND USES THEREOF
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Pub. No.: WO/2018/106922 International Application No.: PCT/US2017/065121
Publication Date: 14.06.2018 International Filing Date: 07.12.2017
IPC:
A01N 43/52 (2006.01) ,A01N 43/50 (2006.01) ,A61K 31/415 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
50
1,3-Diazoles; Hydrogenated 1,3-diazoles
52
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
50
1,3-Diazoles; Hydrogenated 1,3-diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
Applicants:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED [US/US]; 223 Grinter Hall Gainesville, FL 32611, US
Inventors:
HUIGENS, Robert, William; US
ABOUELHASSAN, Yasmeen; US
BASAK, Akash; US
Agent:
BAKER, C., Hunter; US
Priority Data:
62/431,35307.12.2016US
Title (EN) N-ARYLATED ANALOGUES AND USES THEREOF
(FR) ANALOGUES N-ARYLÉS ET UTILISATIONS DE CEUX-CI
Abstract:
(EN) The present invention provides novel compounds of Formula (I´) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and/or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and/or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and/or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).
(FR) La présente invention concerne de nouveaux composés représentés par la formule (I), et des sels pharmaceutiquement acceptables, des solvates, des hydrates, des polymorphes, des co-cristaux, des tautomères, des stéréoisomères, des dérivés marqués de façon isotopique, des promédicaments et des compositions correspondantes. L'invention concerne également des procédés et des kits comprenant les composés ou compositions de l'invention et destinés à éliminer un micro-organisme (par exemple bactéries, champignons, virus, protozoaires ou parasites multicellulaires), à prévenir et/ou à traiter des maladies infectieuses (par exemple infections par des micro-organismes, infection bactérienne, infection due à la fibrose kystique, infection par un corps étranger, infection des voies urinaires ou infections conduisant à la formation de biofilms), à lutter contre des biofilms et/ou à éradiquer ceux-ci (par exemple biofilms bactériens), à prévenir la formation d'un biofilm, à stériliser une surface et/ou à éradiquer des cellules persistantes (par exemple chez un sujet nécessitant un tel traitement ou chez un sujet comprenant un biofilm).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)