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1. (WO2018106918) NEURONAL SURVIVAL AND AXONAL REGENERATION THROUGH INCREASING MITOCHONDRIAL MOTILITY
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Pub. No.: WO/2018/106918 International Application No.: PCT/US2017/065113
Publication Date: 14.06.2018 International Filing Date: 07.12.2017
IPC:
A61K 31/11 (2006.01) ,A61K 31/351 (2006.01) ,A61K 31/665 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
11
Aldehydes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
351
not condensed with another ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
665
having oxygen as a ring hetero atom, e.g. fosfomycin
Applicants:
THE CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, Massachusetts 02115, US
Inventors:
HE, Zhigang; US
SCHWARZ, Thomas L.; US
ROMAIN, Cartoni; US
Agent:
RESNICK, David S.; US
EISENSTEIN, Ronald I.; US
FITZGERALD, Mark J.; US
BENN, Susanna C.; US
CROSBY, David F.; US
DE REGE THESAURO, Francesco; US
HUFF, Shayne Y.; US
KLING, Nicole D.; US
MILLS, Tari W.; US
PATIL, Kalyani; US
PTASHKA, Teresa A.; US
SUBRAMANIAN, Srividya; US
SUMMERFORD, Candace M.; US
Priority Data:
62/431,20607.12.2016US
Title (EN) NEURONAL SURVIVAL AND AXONAL REGENERATION THROUGH INCREASING MITOCHONDRIAL MOTILITY
(FR) SURVIE NEURONALE ET RÉGÉNÉRATION AXONALE PAR AUGMENTATION DE LA MOTILITÉ MITOCHONDRIALE
Abstract:
(EN) Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.
(FR) La présente invention concerne des compositions et des procédés pour favoriser la survie ou la régénération d’axones dans des neurones par augmentation de la motilité mitochondriale dans le neurone. L’invention concerne en outre des procédés de traitement d’une lésion neuronale et une maladie et des troubles caractérisés par une lésion neuronale. L’invention concerne des agents qui augmentent l’activité Armcx1, tels qu’un polypeptide Armcx1 ou des vecteurs comprenant un acide nucléique codant pour le polypeptide Armcx1, pour utilisation dans les procédés. L’invention concerne en outre une composition pharmaceutique comprenant les agents, et des procédés d’identification d’agents additionnels.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)