WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018106907) FUSED BICYCLIC ALKYLENE LINKED IMIDODICARBONIMIDIC DIAMIDES, METHODS FOR SYNTHESIS, AND USES IN THERARY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/106907 International Application No.: PCT/US2017/065095
Publication Date: 14.06.2018 International Filing Date: 07.12.2017
IPC:
A61K 31/155 (2006.01) ,A61K 31/404 (2006.01) ,C07C 279/26 (2006.01)
Applicants: NOVATARG, INC.[US/US]; First Flight Venture Center 2 Davis Drive Research Triangle Park, NC 27709, US
Inventors: BATCHELOR, Kenneth; US
COBB, Jeffery, E.; US
GUDMUNDSSON, Kristjan, S.; US
HENKE, Brad, R.; US
TAVARES, Francis, X.; US
Agent: FIX, Amy, H.; US
FOX, Jennifer, L.; US
BAUM, Allen, R.; US
ALI, Bashir, M.; US
Priority Data:
62/431,47508.12.2016US
62/454,14703.02.2017US
Title (EN) FUSED BICYCLIC ALKYLENE LINKED IMIDODICARBONIMIDIC DIAMIDES, METHODS FOR SYNTHESIS, AND USES IN THERARY
(FR) DIAMIDES IMIDODICARBONIMIDIQUES LIÉS À UN ALKYLÈNE BICYCLIQUE FUSIONNÉ, PROCÉDÉS DE SYNTHÈSE ET UTILISATIONS DANS UNE THÉRAPIE
Abstract: front page image
(EN) The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3- yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3- yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5' adenosine monophosphate-activated protein kinase (AMPK).
(FR) La présente invention concerne de nouveaux diamides imidodicarbonimidiques liés à un alkylène bicyclique fusionné. En particulier, la présente invention porte sur des diamides imidodicarbonimidiques liés au N-[2-(indol-3-yl)alkylène] et sur des diamides imidodicarbonimidiques liés au N-[2-(pyrrolopyridine-3-yl)alkylène] (composé de la formule (I) ou de la formule (II)) et sur leurs utilisations. Les composés de la présente invention sont supposés être des composés sélectifs de transporteur de cations organiques, utiles pour le traitement de maladies et d'états provoqués par une activité réduite de la protéine kinase activée par le monophosphate d'adénosine 5' (AMPK).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)