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1. (WO2018106885) COMPOSITIONS AND METHODS FOR IN VITRO CULTIVATION AND/OR EXPANSION OF REGULATORY T CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/106885 International Application No.: PCT/US2017/065055
Publication Date: 14.06.2018 International Filing Date: 07.12.2017
IPC:
C12N 5/0783 (2010.01)
Applicants: EAST CAROLINA UNIVERSITY[US/US]; 210 Spilman Building Greenville, NC 27858, US
Inventors: WILKINSON, Daniel Stephen; US
MANNIE, Mark D.; US
Agent: BONNEN, Alice M.; Myers Bigel, P.A. PO Box 37428 Raleigh, NC 27627, US
Priority Data:
62/430,99107.12.2016US
Title (EN) COMPOSITIONS AND METHODS FOR IN VITRO CULTIVATION AND/OR EXPANSION OF REGULATORY T CELLS
(FR) COMPOSITIONS ET MÉTHODES DE CULTURE ET/OU DE CROISSANCE IN VITRO DE LYMPHOCYTES T RÉGULATEURS
Abstract: front page image
(EN) FOXP3+ regulatory T cells (Tregs) can represent powerful adoptive immunotherapies for autoimmune diseases, metabolic diseases, and other chronic inflammatory diseases. The present invention is related to the ability to maintain and expand stable Treg lines and can provide insight into FOXP3+ Treg physiology and can enable feasible strategies of Treg-based immunotherapy.
(FR) Les lymphocytes T régulateurs FOXP3+ (Tregs) peuvent représenter des immunothérapies adoptives puissantes pour des maladies auto-immunes, des maladies métaboliques et d'autres maladies inflammatoires chroniques. La présente invention concerne la capacité de maintenir et de faire croître des lignées Treg stables et peut fournir un aperçu de la physiologie des Tregs FOXP3+ et peut permettre la mise en oeuvre de stratégies possibles d'immunothérapie basée sur Tregs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)