Search International and National Patent Collections

1. (WO2018106864) ANTIBODIES AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/106864    International Application No.:    PCT/US2017/065014
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 08 00:59:59 CET 2017
IPC: A61K 39/395
C07K 16/28
Applicants: AGENUS INC.
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: VAN DIJK, Marc
MUNDT, Cornelia Anne
RITTER, Gerd
SCHAER, David
WOLCHOK, Jedd David
MERGHOUB, Taha
WILSON, Nicholas Stuart
SAVITSKY, David Adam
FINDEIS, Mark Arthur
ZAPPASODI, Roberta
HOLMGAARD, Rikke Bæk
CUILLEROT, Jean-Marie
PROSCURSHIM, Igor
SHEBANOVA, Olga
Title: ANTIBODIES AND METHODS OF USE THEREOF
Abstract:
Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.